Up to 50 people have been injured after two trains collided head-on in Switzerland during rush hour.

The commuter train and high-speed train collided in Rafz, north of Zurich near the German border, at 6.45am on Friday morning.

Police spokeswoman Cornelia Schuoler told the NZZ the accident caused multiple injuries, but did not say how serious they were.

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A rescue worker was quoted by a local newspaper as saying 49 people had been injured in the crash, according to Sky News.

Photos from the scene show train carriages titled but not completely overturned.

However, the Associated Press and Reuters had the number of injured at five, citing Zurich cantonal police.

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